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In glucose metabolism, vitamin D response elements in the insulin gene promoter allow supplementation to directly stimulate insulin secretion, upregulate -cell proliferation genes, and boost peripheral insulin sensitivity (46)

Johnson et al., 2009)

The recently published phase-3 clinical trials data of the drug donanemab, which targets amyloid plaque, have shown to reduce cognitive decline in AD patients, but also cause brain haemorrhage (bleeding) and edema (swelling) in some of these patients

Particularly, we found in subgroup analyses those participants who lost weight or with high -diversity had more down-expressed genes in CD16 + monocytes compared to those whose weight remained stable or with low -diversity (Fig