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Homocysteine metabolism in cardiovascular cells and tissues: Implications for hyperhomocysteinemia and cardiovascular disease

In the purine metabolism pathway, there were notable increases in xanthine and hypoxanthine concentrations, which rose by 26.6-fold and 18.3-fold, respectively, while ADP and AMP levels were downregulated, with slight decreases observed in adenosine and adenine (Figure 4C)