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10.1016/j.redox.2020.101576 Redox Biol

The Clostridium botulinum bacteria that produce Botox can cause botulism, a serious nervous system disorder that affects breathing

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Biofilm growth is linked to the activation of highly conserved stress-response signaling cascades, primarily the heat shock protein (Hsp) network (Hsp90/Hsp70 and their co-chaperones), the calcineurin signaling pathway, and downstream gene expression responses, all of which help maintain protein folding, cell wall integrity, and ionic homeostasis under drug- and host-imposed stressors (Roy and Tamuli, 2022