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Three major protein subfamilies have been reported to exhibit glutathione transferase activity: Cytoplasmic, mitochondrial and microsomal GSTs (4,5)

Improved hemophagocytic lymphohistiocytosis index predicts prognosis of adult Epstein-Barr virus-associated HLH patients

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For example, Shikonin, a natural naphthoquinone isolated from the roots of Lithospermum erythrorhizon , can induce apoptosis and necrotic of GBM cells (35) by inhibiting EGFR phosphorylation and decreasing phosphorylation of EGFR downstream molecules, including AKT, P44/42MAPK and PLC1