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[DOI] [PubMed] [Google Scholar] 104.Chen Z., Zhong C

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It is worth noting that thiostreptozotocin promotes ferroptosis by downregulating GPX4 mRNA and GPX levels mainly by decreasing intracellular STAT3 and p-STAT3 expression rather than affecting SLC7A11 protein expression [140]

Moreover, owing to its significant intratumoral heterogeneity, the positive responses observed in a small cluster of patients to immunotherapies or other treatment modalities cannot be extrapolated to represent the overall treatment sensitivity of GBM