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we found that ROS accumulated in LCS3-sensitive cancer cell lines H23 and H1650, but not in the resistant HCC2279 cancer cell line or the non-transformed HPL1D lung cell line (Fig

Importantly, this pathway is enzymatically tractable, as the enzymes that control CoQ 10 reduction are druggable oxidoreductases, making the CoQ 10 axis a promising pharmacological entry point for ferroptosis-based cancer therapy

Synthetic peptides can be exact copies of natural sequences, modified sequences that resist degradation, or even entirely new sequences created to bind to specific receptors

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