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SSG represents an adaptive response that protects cells from ferroptosis under GSH-limiting conditions

Applications Total Glutathione Colorimetric assay kit measures total, oxidized and reduced glutathione in wide range of samples such as blood, plasma, serum, cultured cells and tissues Estimating glutathione in cells is one of the ways to measure oxidative stress and this assay is also vital for mitochondrial toxicity screening GSH/GSSG ratio decreases in many pathological diseases such as cancer, diabetes, cardiovascular disorders, artherosclerosis, Parkinsons and Alzheimers 3, 4 and thus estimating glutathione is vital in this area of research

Conversely, HCC cells with increased extracellular lactate levels are more resistant to ferroptosis induced by RSL3 and erastin [102]

Other parameters were valued as follows: F v / F m = ( F m F o )/ F m