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The in-vitro skin permeation study results showed that the nanovesicles of sulforaphane had an increased skin penetration compares to free drug as well as after performing antiproliferative activity of free drug and nanovesicles it was found that the anticancer activity of Sulforaphane ethosomes has greater anticancer activity compared to free Sulforaphane after tested on SK-MEL 28 [314]