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Excess iron ions can also lead to changes in the activity of certain metabolic enzymes, notably a significant increase in lipoxygenase (LOX) activity, which is primarily responsible for lipid oxidation [17]

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doi: 10.1016/j.clnu.2005.02.002 Gleeson M, Pyne DB: Special feature for the Olympics: effects of exercise on the immune system: exercise effects on mucosal immunity

These differences provide a basis for selective targeting, as supported by studies showing that fungal NADP-GDH inhibitors are effective at low concentrations against fungi but exhibit minimal effects on human cells [28]