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Once bound to these receptors, it can initiate a cascade of biochemical reactions that lead to long - term changes in neuronal function and plasticity

In a randomized trial involving SLE patients, significant reduction in NET complexes was observed in individuals with the STAT4 risk allele who received Tofacitinib treatment, while no impact was observed in STAT4 risk allele-negative patients or those in the placebo group (134)