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Side effects These may include: feeling sick (nausea) vomiting appetite changes and difficulty swallowing sore mouth or mouth ulcers skin and nail changes numbness in the hands or feet ringing in the ears or hearing loss constipation or diarrhoea, and hair loss or thinning

In the years leading up to menopause, known as perimenopause , people may notice that their bodies change in response to these lower levels of estrogen

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Furthermore, thiosulfate treatment resulted in no noticeable adverse haemodynamic or respiratory effects when given as either a bolus or a constant infusion