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Pinocytosis, associated with fluid-phase uptake, includes macropinocytosis, clathrin-mediated endocytosis, caveolin-mediated endocytosis, and clathrin/caveolae-independent endocytosis, occurring in nearly all eukaryotic cells [75]

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The type I form is caused by mutation in the neutrophil cytosolic factor 1 (NCF1) gene, which encodes the p47-PHOX (phagocyte oxidase) protein