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Another antagonist of MC1R, undecylenoyl phenylalanine, also induced significant lightening of pigmented lesions when applied twice daily at 2% in patients with melasma or SL [118, 119]

Correspondingly, senescent cells may also be a factor in persistent inflammatory reactions (Liu et al

In Pinealons case, the compound comes from a nootropic and neuroprotective polypeptide complex called Cortexin, whose neuropeptide fractions are derived from the brains of cows and pigs.3 Pinealons simpler, ultra-short structure may imbue it with higher stability, better tissue penetration, and a lower risk of hazardous immune responses than its more intricate polypeptide predecessor.4 Research suggests that Pinealons mechanism of action involves activating the gene expression and the synthesis of proteins associated with neuronal activity, as well as decreasing the intensity of neuronal cell death.5 More specifically, Pinealon is believed to enter cells and interact with DNA sequences, thereby influencing the activities of several key factors related to cellular and bodily processes

10.1001/archderm.118.1.23 Bell IR, Cunningham V, Caspi O, Meek P, Ferro L: Development and validation of a new global well-being outcomes rating scale for integrative medicine research