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The HMO6 cell line is an immortalized human microglial model generated by v-myc retroviral transduction of embryonic telencephalon-derived primary microglia ( 2535 induces only limited cytokine secretion (primarily IL-8 and TNF) compared to the broad cytokine profile produced by primary human microglia

injections of 200 nmol kg 1 MK-801 (n = 8 mice and n = 4 cages), 600 nmol kg 1 MK-801 (n = 7 mice and n = 4 cages) or vehicle (isotonic saline, n = 7 mice and n = 4 cages) for 7 days

282,283 Several natural phytochemicals, such as curcumin, have also been shown to inhibit NF-B nuclear translocation while simultaneously activating Nrf2, an antioxidative pathway

Recent studies in solid cancers have found that APR-246 can also induce p53-independent cell death