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Sympathetic nervous system dysfunction in fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, and interstitial cystitis: a review of case-control studies

Because approximately 70% of the human immune system resides in the gut-associated lymphoid tissue (GALT), maintaining a healthy intestinal environment is paramount for systemic immune regulation

While coffee won't "ruin" the supplement, the heat and caffeine can slightly alter the digestive environment, so giving the supplement a head start is ideal

The US FDA has studied the data of 254 medicines in the LTKB-BD (Liver Toxicity Knowledge base Benchmark Dataset) and found that regardless of the administered dose, drugs metabolized by cytochrome P450 (CYP) enzymes CYP1A2, CYP2C8/CYP2C9 and CYP3A5 were more likely to cause DILI (Yu et al., 2014)