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10,278,279,288 MTORC1 inhibition (e.g., rapamycin, RapaLink-1) extends lifespan by enhancing autophagy and metabolic regulation, with clinical trials targeting immunosenescence

Verhagen AP, Damen L, Berger MY, et al

Gene Ontology (GO) enrichment analysis revealed a high degree of colocalization of ASXL1 and BRD4 on the genes associated with the regulation of RNAs and ribosome functions (Fig