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[DOI] [PMC free article] [PubMed] [Google Scholar] VelsquezJimnez, D

Research indicates that reactive oxygen species (ROS) in cigarette smoke causes hyaluronan fragmentation in bronchial epithelial cells , compromising barrier integrity by interacting with the epithelial surface receptor layilin and facilitating a RhoA/Rho kinase-mediated reduction in E-cadherin expression at both the genetic and protein levels

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Pathophysiological Mechanisms of Ocular Nutrition Oxidative Stress and Antioxidant Defense Systems The retinal environment, particularly the macula, exists under conditions of high oxidative stress due to intense light exposure, elevated oxygen consumption, and abundant polyunsaturated fatty acids