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Alexander N

10.4161/auto.6398 Autophagy 170 KoningsB.VillatoroL.Van den EyndeJ.BarahonaG.BurnsR.McKnightM.et al (2023)

Effect of chemically modified tetracycline on transforming growth factor-beta1 and caspase-3 activation in liver of septic rats

In human monocytes and macrophages, the inhibition of the autophagy pathway drives the formation of the NLRP3 inflammasome, while increased autophagic flux reduces the secretion of IL-1, suggesting the role of autophagy impairment in driving inflammasome activation [192]