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By measuring the amount of ROS produced when the lung cancer A549 and Calu-3 cell lines were co-treated with curcumin and PTX using a fluorescent probe, a study reported that the combination resulted in higher levels of ROS and showed stronger anticancer effects, such as the inhibition of cell proliferation, as well as induction of apoptosis and cell cycle arrest, compared with curcumin or PTX treatment alone (77)

Statistical analysis All statistical analyses were performed via a one-way analysis of variance followed by the Tukey HSD post hoc test, using Kaleida Graph 4.0J (Hulinks, Tokyo, Japan)