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The difference between 5 units and 7 units on a syringe is tiny, and that small measurement error could mean a 40% dosing difference

The HFI series of compounds, e.g., 37 (HFI 419) identified in 2008 after the virtual screening are much more drug-like than the hexapeptides 11 (AL-11), 12 (IVDE77), and the potent macrocyclic Ang IV analogue 23 (HA08) and can hopefully after further systematic optimization be converted into bioactive small molecules with capacity to cross the blood-brain barrier

The VEGFA and IL8 protein expression levels were semi-quantitatively evaluated using the H -score system

they need to be destroyed by something as soon as theyve reached the end of their usefulness