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Accordingly, increasing cerebral insulin levels has been proposed as a strategy to halt the neurodegenerative processes associated with Alzheimer's disease (AD) (160)

Tackling brain tumors with Exosome-Based strategies Brain tumors, especially, glioblastoma represent some of the most formidable challenges in oncology due to their aggressive progression, invasive behavior, and the significant obstacles posed by the BBB to therapeutic delivery

The starting dose of probenicid is usually 250 mg twice daily but it may need to be increased to up to 1 g twice daily

Peer review Peer review information Nature Cell Biology thanks Qingran Kong and the other, anonymous, reviewer(s) for their contribution to the peer review of this work