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Meanwhile, GST catalyzes the formation of platinum-GSH compound and accelerates drug inactivation via increasing drug solubility (Rabik and Dolan, 2007)

Wang Z-H, Peng W-B, Zhang P, Yang X-P, Zhou Q

C677T: G/G: typical function A/G: enzyme function decreased by ~40% A/A: enzyme function decreased by 7080% A1298C: T/T: typical function G/T: slightly decreased function G/G: enzyme function decreased by ~20% Are there other MTHFR variants that matter