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2022 NEJM) randomized 2,539 adults with overweight or obesity (without diabetes) to tirzepatide 5 mg, 10 mg, 15 mg, or placebo for 72 weeks

The relative simplicity of the molecule (a 16-amino acid fragment) makes it straightforward to synthesize, which contributes to reliable supply

(2004) The Journal of Clinical Endocrinology & Metabolism Study in diet-induced obese mice examining AOD 9604 effects on metabolic syndrome, visceral fat, and insulin sensitivity