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Ann N Y Acad Sci 1201:96103

10.1186/1472-6882-14-457 188 SolimanM

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This mechanism is widely explored in aesthetic procedures, such as facial rejuvenation, due to its ability to promote structural skin renewal with long-lasting results.18 Absorption and Toxicokinetics Phenol absorption into the bloodstream after cutaneous application is intense and rapid, with urinary recovery of 70% within 30 minutes and 85%95% within 24 hours.17,19 Even small amounts can reach significant serum levels, making strict dose control and the use of targeted application techniques essential.16 Studies indicate that cutaneous absorption is little influenced by the concentration of the applied solution but depends largely on the area of exposed skin.20 In 1971, Piotrowski studied solutions containing phenol at concentrations of 5, 10, and 25 mg/m3 and found that, regardless of concentration, the compound is rapidly absorbed through both the skin and the lungs.21 Metabolism and Elimination When applied to the skin, phenol is rapidly absorbed due to its lipophilic nature and low molecular weight, penetrating the stratum corneum and reaching the systemic circulation