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A framework for voxel-based assessment of biological effect after proton radiotherapy in pediatric brain cancer patients using multi-modal imaging

Additional rating scalespecific diagnostics (eg., leave-one-out analyses and small-study effect assessments) are provided in the Supplement

Acetylation can neutralize the positive charge of lysine residues, thereby diminishing the binding affinity between DNA and histones, leading to a relaxation of chromatin structure, thereby allowing transcriptional regulatory factors to bind and promoting gene expression

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