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One hypothetical explanation is an adverse oxidative effect of unmetabolized FA (UMFA) on vitamin B12 homeostasis ( High serum cobalamin (hypercobalaminemia) Maintaining adequate vitamin B12 status through diet and supplementation (as needed) is unquestionably important for health

It can competitively inhibit MET channels, thereby reducing gentamicin uptake into hair cells, and may also interfere with prestin function, indirectly mitigating the toxic effects on cochlear amplification

In particular, a peptide inhibitor of JNK kinase-mediated mitochondrial cell death pathway, D-JNKI-1 peptide, has shown promises in protecting the cochlea against noise-induced and aminoglycoside induced HC loss when delivered directly into the scala tympani or locally to the round window membrane (Wang et al., 2003b, 2007

Serum concentrations and clinical effects after intravenous, intramuscular and oral administration