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Role of TMAO in increasing cardiovascular disease risk A choline-rich diet puts a person at risk of increased TMAO levels [16], which is directly correlated to an increased CVD risk [99]

Importantly, this inhibition occurred without bactericidal effects on gut microbiota, as confirmed by preserved alpha diversity and the persistence of TMA-producing genera such as Collinsella and Clostridium post-treatment

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2.3 Alkaloids: mitochondrial targeting and metabolic reprogramming Alkaloids are a class of nitrogen-containing organic compounds in which the nitrogen atom typically exhibits basicity and is often protonated to carry a positive charge under physiological pH conditions