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These cells appear to contribute to the aging process and age-related diseases through the senescence-associated secretory phenotype (SASP), which fosters a pro-inflammatory environment detrimental to tissue function and integrity

They help manage swelling and pain locally without introducing systemic compounds that interfere with healing

The sponsor must commit to submit comprehensive safety and efficacy data within a maximum period of 6 years after registration to convert the provisional registration to a full registration

analyzed mutations in 232 genetically-profiled NSCLC patients and found that about half of the local recurrences, post-radiotherapy occurred in tumors with KEAP1/NFE2L2 mutations, indicating these mutations are major drivers of clinical radioresistance [25]