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Symptoms of this disorder often start during infancy and can include drowsiness, seizures that may be accompanied by involuntary jerking muscle movements of the arms, legs or head (myoclonic seizures), and intellectual disability

Sorafenib and erastin can activate the NFE2L2 pathway, resulting in the expression of antioxidant genes such as quinone oxidoreductase 1 (NQO1) and metallothionein 1G (MT1G) in HCC cells (87, 89)

Dasgupta D, Nakao Y, Mauer AS, Thompson JM, Sehrawat TS, Liao CY, Krishnan A, Lucien F, Guo Q, Liu M, Xue F, Fukushima M, Katsumi T, Bansal A, Pandey MK, Maiers JL, DeGrado T, Ibrahim SH, Revzin A, Pavelko KD, Barry MA, Kaufman RJ, Malhi H

Quist DA, Diaz DE, Liu JJ, Karlin KD (2017) Activation of dioxygen by copper metalloproteins and insights from model complexes