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The SHH-activated group can further be divided into four subgroups, and the non-WNT/non-SHH group can be divided into eight subgroups by DNA methylation or transcriptome profiling [1]

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Figure 2 For the above, intermediate melanocytic tumors may be subclassified into: i) a classical subgroup (dysplastic nevus and melanoma in situ ), which is placed within the morphologic and molecular progression spectrum of classical melanoma subtypes (superficial spreading and, possibly, nodular

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