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These exons encode, apart from the 5 untranslated region, a portion of the signal peptide(s) for secretion, and their use seems dependent on two different promoters that are regulated in a tissue-specific manner 17

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For example, the redox activitiy of p66Shc within mitochondria has been shown to generate H 2 O 2 in the absence of superoxide through oxidation of cytochrome c (Giorgio et al., 2005)