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Furthermore, reactive persulfides/polysulfides, including cysteine persulfides (CysSSH), have been reported to form endogenously, from both small molecule species and from proteins, in high amounts in mammalian cells and tissues, including human plasma 11

Thus, radiation-induced Drp1-mediated mitochondrial fission serves as a critical pro-survival mechanism that inhibits apoptosis, promotes mitophagy and metabolic reprogramming, and drives radioresistance, whereas blocking fission shifts the balance toward mitochondrial elongation, cell cycle arrest, and enhanced radiation sensitivity -underscoring Drp1 as a compelling therapeutic target to overcome radioresistance

doi:10.1093/clinchem/30.6.884

Richter-Landsberg, C