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Finally, the collected cells were incubated with JC-1 (10 mM) in the dark at 37 C for 30 min

doi: 10.1016/S0098-2997(01)00010-3 31 XieQWChoHJCalaycayJMumfordRASwiderekKMLeeTDet al

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Although ferroptosis, an iron-dependent form of cell death, has numerous pathophysiological features similar to those of SLE, such as intracellular iron accumulation, mitochondrial dysfunction, lipid metabolism disorders and concentration of damage associated-molecular patterns (DAMPs), only a few reports have demonstrated that ferroptosis is involved in SLE progression and that the role of ferroptosis in SLE pathogenesis continues to be neglected