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(7) Sarah Wrigley, Donia Arafa, and Daniela Tropea (2017) Insulin-Like Growth Factor 1: At the Crossroads of Brain Development and Aging Frontiets in Cellular Neuroscience, 2017 Feb 1, Volume 11, Page 14

The development of GC involves multiple factors, including Helicobacter pylori and Epstein-Barr virus infections, exposure to carcinogens, suppression of tumor suppression genes, abnormal cell apoptosis, and disruption of cell cycle regulation