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The latter mechanism is triggered by the acidic microenvironment (pH =5.5), which promotes MIL-100 framework degradation, while hyaluronidase (HAase) simultaneously degrades the surface HA layer

While short-term side effects like vertigo, increased body temperature, mood swings, and nausea can occur, long-term side effects are less well-documented due to limited research

Biomarkers of lysosomal and inflammatory pathology are also starting to be explored in PD as markers of poor outcomes

104 Introduction of specific agents under development Among the promising agents under development, Verve Therapeutics is developing in vivo base editing medicines with the goal of inactivating PCSK9 or ANGPTL3