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The mechanism by which the training strategies pointed out in the case description promote muscular hypertrophy desired by bodybuilding athletes are the following: resistance training using high loads Resistance exercise is an important activator of mTOR pathway because mechanical stretch caused by repeated contractions damages the sarcolemma (muscle cell plasma membrane), by activating the enzyme phospholipase D, which hydrolyzes the phospholipids

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The standard change of Gibbs free energy was higher than that with the lactate group (Fig