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Ileum and colon chips can support lower oxygen environments (11 mmHg) 108 and dense microbial communities, enabling evaluation of host-microbiome co-metabolism

Variables to track include weight used, repetitions completed, and perceived exertion level

Patients who implement and sustain meaningful dietary changes, regular physical activity (150-300 minutes weekly of moderate-intensity exercise per US Physical Activity Guidelines), and behavioral modifications may maintain some benefits after medication discontinuation, whereas those unable to adopt lifestyle changes typically experience rapid relapse