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Metal ion imbalance and oxidative stress trigger the overproduction of A by activating - or -secretases and inhibiting -secretase, and also cause tau hyperphosphorylation by activating protein kinases, such as glycogen synthase kinase-3 (GSK-3), cyclin-dependent protein kinase-5 and MAPKs, and inhibiting protein phosphatase 2A (Wang et al., 2020)

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Safety, Sourcing, and Science-Based Use When used under professional supervision, peptides are generally well-tolerated

Liang R, Wang JH, Liu F, Duan XH, Hao XC, Zhang L, Wang M , Liu X, Guo YH, Wang Z, Tang H, Yang L