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The molecular basis of ferroportin-linked hemochromatosis

In further embodiments, the invention encompasses a method of providing muscular therapy by contacting a cell expressing NNMT with a NNMT inhibitor (such as a cation of Formula I or IA, or otherwise disclosed herein) and one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulates intracellular NAD+ levels to provide muscular therapy

Standard laboratory assays measure total serum B12, which includes vitamin bound to transport proteins

This clinical study with NAD+ IV infusion demonstrates improved depression and anxiety symptoms in 50 individuals with cravings and addictive behaviors.