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Variant-to-gene mapping in human microglial cell models with CRISPR validation implicates RTFDC1 at the Alzheimers disease CASS4locus

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In germplasm banks, the preservation of genetic material from animals has advanced significantly over the past few decades [4]

Despite the outstanding characteristics of exosome-based mRNA delivery systems over LNPs, the challenges of using exosomes such as large-scale isolation and purification for subsequent clinical applications remain a paramount setback [107, 113]