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Acknowledgements The authors are thankful to the Department of Biotechnology, Ministry of Science & Technology, Government of India for the Bioinformatics infrastructure facility at Jamia Hamdard under the BTISNet program

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Target gene fold change was calculated using the geometric mean of the 3 housekeeping genes with the Cq method

Additionally, graphene-based electrochemical chips capable of simultaneously detecting O 2 , H 2 O 2 , and OH, gas chromatography of exhaled breath (to detect volatile ROS metabolites), and PET tracers such as 13 F-ROStrace hold revolutionary potential for clinical application