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An upregulation of the Nox4 expression with downregulation of the catalase expression and/or activity in diabetes increases the hydrogen peroxide concentration which promotes retinal neovascularization through the VEGF signaling pathway [82]

Cerebral small vessel disease: from a focal to a global perspective

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Similar to BCAT, the expression levels or activities of BCKDH and BCKDK may potentially serve as markers for the diagnosis or prognosis of certain types of tumors