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Among in-frame interacting proteins, several candidates encode protein chaperones or co-chaperones that regulate protein folding and stability (Extended Data Fig

The female albino Wistar rats were regularly checked for their weight, locomotor activity and anxiety during the study and backed by evaluation of various parameters like thyroid hormone profile, histopathology of the thyroid gland, antioxidant (CAT, GSH, GPx, SOD) level, MDA (indicator for lipid peroxidation), nitrite level, total protein content in blood serum and thyroid homogenate

These results obtained in vitro suggest that DSIP exerts a direct action on the differentiation of several pituitary precursor cells

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