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doi: 10.3389/fmicb.2015.00742

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[99] However, this concept was conclusively disproved when it was demonstrated that mice, which were genetically altered to accumulate mtDNA mutations at an accelerated rate to age prematurely, but their tissues do not produce more ROS as predicted by the 'Vicious Cycle' hypothesis

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Therefore, in PD Nrf2 activation and BBB preservation may cooperate to fight oxidative and inflammatory stressors [55]

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