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Finally, a four-year, multicenter, clinical trial in 421 diabetic patients with distal symmetric sensorimotor polyneuropathy found no difference between oral administration of 600 mg/day of lipoic and placebo on the primary endpoint, a composite score that assessed neuropathic impairment of the lower limbs and nerve conduction (78)

Biomaterials 8(5):784791 Kim JH et al (2011) The inhibition of retinal neovascularization by gold nanoparticles via suppression of VEGFR-2 activation

Injection Therapy Outcomes Research indicates B12 injections rapidly restore serum levels and reverse neurological symptoms in most patients