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The USPSTF found no head-to-head studies demonstrating that any of these screening strategies are more effective than others, although they have varying levels of evidence supporting their effectiveness, as well as different strengths and limitations. [711] The USPSTF again included CTC as a CRC screening method in the most recent May 2021 revised Final Recommendation Statement, which ( included the topline recommendations [t]he USPSTF recommends screening for colorectal cancer in all adults aged 50 to 75 years (Grade A) and [t]he USPSTF recommends screening for colorectal cancer in adults aged 45 to 49 years (Grade B)