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investigated Hachimijiogan (HJG), revealing its ability to induce neurite outgrowth in PC12 cells by acting as a nerve growth factor (NGF)

Because of similar pharmacological properties, it is reasonable to expect similar risk with the concomitant use of other CNS depressant drugs with opioid analgesics (see PRECAUTIONS, Drug Interactions)

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Despite these considerations, we believe that host factors in erythrocytes are promising drug targets for the reasons stated in the preprint: (a) erythrocytes serve as a vital host to the malaria life cycle and (b) variation in erythrocyte function in certain diseases confer a selective advantage to the host, suggesting multiple potential drug targets for malaria treatment