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Moreover, an excess of fatty acids and lipotoxicity predisposes to inflammation and type 2 diabetes mellitus, inducing macrophage iron accumulation via FTH1 gene activation, which encodes the ferritin H subunit [35,36]

Mentions of tianeptine as a remedy for withdrawal from or substitute for other substances (e.g., phenibut, kratom) highlights one of several dark sides to tianeptine use in our sample: it was but one substance in a long line of substances that eventually failed to have the desired benefit-harm ratio

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Further studies have revealed delayed wound recovery in GPX4 siRNA-treated cells 2 days after wounding