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These inhibitors restore GSH content and GPX4 activity, improve mitochondrial membrane potential decline and structural abnormalities such as mitochondrial shrinkage and reduced cristae, downregulate the expression of inflammatory cytokines, and reverse CSE-induced decreases in cell viability and damage to the retinal pigment epithelium-choroid complex

It was also shown that in HepG2 liver cancer cell cultures, MEL inhibited the activity of metalloproteinase 9 (gelatinase) by suppressing the expression of the encoding gene and increasing the levels of the tissue inhibitor of metalloproteinases, TIMP-1, and reducing nuclear translocation of NF-B (237)

Studies on the chemical constituents and bioactivities of three marine organisms

The build-up of DHA favours the development of cataracts by exacerbating oxidative stress, eventually resulting in damaged lens proteins [8,9]