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also demonstrated that in TNBC cells, the SOX2-ABCG2-TWIST1 pathway plays a significant role in regulating tumorigenicity and chemoresistance [195]

L-asparaginases also exhibit glutaminase activity required for durable therapeutic effects against acute lymphoblastic leukemia (243)

Their advantageous properties, including low molecular weight, minimal immunogenicity, facile chemical synthesis, robust tissue penetration, and an expansive target scope, position them as compelling alternatives to antibodies for addressing the cardinal limitations of PROTACs, namely poor selectivity, off-target toxicity, and inadequate delivery efficiency (Fig